Search results for "Ageing Cytokines Eicosanoids Genetics Inflammation Longevity TLR4"

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LPS-mediated production of pro/anti-inflammatory cytokines and eicosanoids in whole blood samples: Biological effects of +896A/G TLR4 polymorphism in…

2011

Toll-like receptors (TLRs) are the principal mediators of rapid microbial recognition: the lipopolysaccharide (LPS) receptor TLR4 seems to have a paradigmatic role. Single nucleotide polymorphisms (SNPs) in the TLR4 gene, such as +896A/G, known to attenuate receptor signaling, have been described. The +896A/G SNP is significantly less frequent in patients with myocardial infarction, Alzheimer's disease or prostate cancer, whereas it is overrepresented in centenarians. To clarify and confirm the biological effects of +896A/G SNP and its role in the pathophysiology of age-related diseases and longevity, we assessed the levels of IL-6, TNF-α, IL-10 and eicosanoids (LTB4 and PGE2) in LPS-stimul…

AdultLipopolysaccharidesMaleAgingAgeing Cytokines Eicosanoids Genetics Inflammation Longevity TLR4PopulationInflammationSingle-nucleotide polymorphismBiologyLeukotriene B4Polymorphism Single NucleotideDinoprostonemedicineHumansSNPeducationReceptorSettore MED/04 - Patologia Generaleeducation.field_of_studyMiddle AgedToll-Like Receptor 4ItalyEicosanoidImmunologyTLR4CytokinesFemalelipids (amino acids peptides and proteins)medicine.symptomDevelopmental BiologyEicosanoid ProductionMechanisms of Ageing and Development
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